H. Ji et al., C-ERBB-2 ONCOGENE RELATED TO P53 EXPRESSION, CELL-PROLIFERATION AND PROGNOSIS IN BREAST-CANCER, Anticancer research, 13(4), 1993, pp. 1147-1152
A series of 193 archival breast cancer biopsies were analysed immunohi
stochemically to detect over-expression of c-erbB-2 oncoprotein. Altog
ether, 59/193 (31%) of the tumours were positive for c-erbB-2, the sta
ining being located at the cell membranes with weak cytoplasmic staini
ng in some samples. The expression of c-erbB-2 was positively correlat
ed with a number of parameters analysed: ductal type, intraductal grow
th pattern, high tumour grade, density of tumour infiltrating lymphocy
tes (TIL), DNA aneuploidy, steroid (ER, PR) receptor negativity, high
S-phase fraction, high mototic frequency, high values of nuclear facto
rs, and accumulation of p53 protein. c-erbB-2 expression showed a weak
association with a low survival probability (p = 0.07) and with a sho
rt recurrence-free survival (p = 0.1). In local tumours or in axillary
lymph node positive tumours, c-erB-2 expression had no significant pr
ognostic value. Also in multivariate analysis, c-erbB-2 expression had
no independent prognostic value superior to the axillary lymph node s
tatus, tumour diameter and mitotic frequency. The results show that c-
erbB-2 expression in related to several histopathological features of
malignancy and cell proliferation in breast cancer, but it has no inde
pendent prognostic value better than that of the established prognosti
c factors.