RANDOMIZED CONTROLLED TRIAL OF SINGLE-DOSE AZITHROMYCIN IN TREATMENT OF TRACHOMA

Blindness due to trachoma is a serious public health issue world wide. The currently recommended treatment of active trachoma with repeated doses of tetracycline eye ointment has many disadvantages. The new aza lide antibiotic azithromycin is effective as a single oral dose in the chemotherapy of genital Chlamydia trachomatis infections, and we have assessed its efficacy for trachoma treatment. We carried out a random ised single-blind comparison of azithromycin (a single oral dose of 20 mg/kg) with conventional treatment (6 weeks of topical tetracycline p lus erythromycin for severe cases) in two villages with endemic tracho ma in The Gambia. The patients were followed up for 26 weeks from the start of treatment by an observer unaware of treatment allocation. By 6 months' follow-up, trachoma had resolved in 76 (78%) of 97 subjects who received azithromycin compared with 70 (72%) of 97 who were treate d conventionally (95% Cl for difference -6% to 18%). Compliance with b oth treatments was good, but that for conventional treatment could pro bably not be achieved outside the research setting. There were no sign ificant differences in treatment effect, baseline characteristics, or re-emergent disease between the treatment groups. Azithromycin was wel l tolerated. As a systemic treatment effective in a single dose it has important potential for trachoma control.