Background: The safety of planned home birth is controversial. This st
udy examined the safety of planned home birth backed up by a modern ho
spital system compared with planned hospital birth in the Western worl
d. Methods: A meta-analysis of six controlled observational studies wa
s conducted, and the perinatal outcomes of 24,092 selected and primari
ly low-risk pregnant women were analyzed to measure mortality and morb
idity, including Apgar scores, maternal lacerations, and intervention
rates. Confounding was controlled through restriction, matching, or in
the statistical analysis. Results: Perinatal mortality was not signif
icantly different in the two groups (OR = 0.87, 95% CI 0.54-1.41). The
principal difference in the outcome was a lower frequency of low Apga
r scores (OR = 0.55; 0.41-0.74) and severe lacerations (OR = 0.67; 0.5
4-0.83) in the home birth group. Fewer medical interventions occurred
in the home birth group, induction (statistically significant ORs in t
he range 0.06-0.39), augmentation (0.26-0.69), episiotomy (0.02-0.39),
operative vaginal birth (0.03-0.42), and cesarean section (0.05-0.31)
. No maternal deaths occurred in the studies. Some differences may be
partly due to bias. The findings regarding morbidity are supported by
randomized clinical trials of elements of birth care relevant for home
birth, however; and the finding relating to mortality is supported by
large register studies comparing hospital settings of different level
s of care. Conclusion: Home birth is an acceptable alternative to hosp
ital confinement for selected pregnant women, and leads to reduced med
ical interventions.