INTERACTION BETWEEN HMG PROTEINS (1-FLANKING SEQUENCE OF THE HUMAN BETA-GLOBIN GENE(2) AND THE NEGATIVE REGULATORY REGION 1(NCR1) IN THE 5')

Authors
QIAN RL CHEN YD HU YL LI MQ WANG ZH XU YL
Citation
Rl. Qian et al., INTERACTION BETWEEN HMG PROTEINS (1-FLANKING SEQUENCE OF THE HUMAN BETA-GLOBIN GENE(2) AND THE NEGATIVE REGULATORY REGION 1(NCR1) IN THE 5'), Science in China. Series B, Chemistry, life sciences & earth sciences, 36(8), 1993, pp. 933-939
Citations number
12
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Science in China. Series B, Chemistry, life sciences & earth sciences → ACNP
ISSN journal
1001652X
Volume
36
Issue
8
Year of publication
1993
Pages
933 - 939
Database
ISI
SICI code
1001-652X(1993)36:8<933:IBHP(S>2.0.ZU;2-G
Abstract
The pattern of high mobility group proteins 1 and 2 (HMG1,2) interacti on with the 5'-flanking sequence of the human beta-globin gene has bee n analyzed by scanning tunnelling microscopy (STM). A 200 bp negative regulatory region in the 5'-flanking sequence of the human beta-globin gene can be folded by HMG proteins 1 and 2 into a circular structure (diameter 70 +/- 6 angstrom) with a linear tail which seems to be a le ft-handed double helix structure.