EFFECT OF ENDOTHELIN, ANGIOTENSIN-II AND ANP ON PROLIFERATION OF VASCULAR SMOOTH-MUSCLE CELLS AND CARDIOMYOCYTES

Authors
WU JM CHENG T SUN SD NIU DD ZHANG JX WANG SH TANG J TANG CS
Citation
Jm. Wu et al., EFFECT OF ENDOTHELIN, ANGIOTENSIN-II AND ANP ON PROLIFERATION OF VASCULAR SMOOTH-MUSCLE CELLS AND CARDIOMYOCYTES, Science in China. Series B, Chemistry, life sciences & earth sciences, 36(8), 1993, pp. 948-953
Citations number
14
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Science in China. Series B, Chemistry, life sciences & earth sciences → ACNP
ISSN journal
1001652X
Volume
36
Issue
8
Year of publication
1993
Pages
948 - 953
Database
ISI
SICI code
1001-652X(1993)36:8<948:EOEAAA>2.0.ZU;2-R
Abstract
By means of cell culture, H-3-thymidine (H-3-TdR) incorporation and c- fos oncogene dot plotting technique, it was found that endothelin (ET) and angiotensin (ANG II) could promote proliferation and DNA synthesi s of cultured vascular smooth muscle cells (VSMCs) and myocardial cell s, and stimulate expression of c-fos oncogene of VSMCs. However, atria l natriuretic peptide (ANP) antagonizes the above effects of ET and AN G II.