Ds. Keeney et Mr. Waterman, REGULATION OF STEROID HYDROXYLASE GENE-EXPRESSION - IMPORTANCE TO PHYSIOLOGY AND DISEASE, Pharmacology & therapeutics, 58(3), 1993, pp. 301-317
Steroid hydroxylase gene expression is multifactorial in nature, being
regulated by tissue-specific, developmental, constitutive and signal
transduction systems. The biochemistry of this complex pattern of regu
lation is not yet clearly elucidated, but studies in several laborator
ies have led to an understanding of specific aspects of regulation, pa
rticularly that involving signal transduction. The complexity of regul
ation appears to be necessary for normal human physiology because of t
he wide variety of steroid hormones produced by these enzymes. Genetic
diseases associated with the steroid hydroxylases provide examples of
how aberrant physiology can result from alterations in the multifacto
rial regulation of steroid hydroxylase gene expression.