EFFECT OF PURINERGIC RECEPTOR ANTAGONISTS SURAMIN AND THEOBROMINE ON TUMOR-INDUCED ANGIOGENESIS IN BALB C MICE/

Authors
GIL M SKOPINSKAROZEWSKA E RADOMSKA D DEMKOW U SKURZAK H ROCHOWSKA M BEUTH J ROSZKOWSKI K
Citation
M. Gil et al., EFFECT OF PURINERGIC RECEPTOR ANTAGONISTS SURAMIN AND THEOBROMINE ON TUMOR-INDUCED ANGIOGENESIS IN BALB C MICE/, Folia biologica, 39(2), 1993, pp. 63-68
Citations number
18
Categorie Soggetti
Biology
Journal title
Folia biologica → ACNP
ISSN journal
00155500
Volume
39
Issue
2
Year of publication
1993
Pages
63 - 68
Database
ISI
SICI code
0015-5500(1993)39:2<63:EOPRAS>2.0.ZU;2-K
Abstract
The purinergic receptor antagonists suramin (SRN) and theobromine (TBR ) were examined for their anti-angiogenic activity in BALB/c mice. SRN or TBR were subcutaneously administered to BALB/c mice in doses of 1- 125 mg/kg body weight on days 0, 1 and 2 after intradermal inoculation of E14/W lung carcinoma cells. It was shown that SRN and TBR inhibite d tumor-related angiogenesis. Accordingly, it may be suggested that pu rinoceptor antagonists may inhibit neovascularization in tumor growth and metastasis.