A. Maitre et al., BIOLOGICAL MONITORING OF OCCUPATIONAL EXPOSURE TO TOLUENE DIISOCYANATE, International archives of occupational and environmental health, 65(2), 1993, pp. 97-100
The study validated the use of urinary toluene diamine (TDA) in postsh
ift samples as an indicator of preceding 8-h exposure to toluene diiso
cyanate (TDI). Nine workers exposed in TDI-based polyurethane foam pro
duction were studied. Their exposure levels varied in 8-h time-average
d samples from 9.5 to 94 mug/m3. The urinary TDA concentrations varied
from 6.5 to 31.7 mug/g creatinine and they were linearly related to t
he atmospheric TDI levels. Approximately 20% of TDI is metabolized to
diamines but their specificity is remarkable to the extent that by ana
lysis for the 2,4- and 2,6-diamino isomers an idea of the percutaneous
absorption may be had.