MALIGNANT ATROPHIC PAPULOSIS - A REPORT OF 2 CASES WITH ALTERED FIBRINOLYSIS AND PLATELET-FUNCTION

Malignant atrophic papulosis is a systemic vaso-occlusive disorder cha racterized by typical skin lesions. We report two new cases with impai rment of blood fibrinolytic activity and alterations in platelet funct ion. The first case showed an increase in plasminogen activator inhibi tor-1 (PAI-1) activity, and the second case had a decrease in platelet aggregation induced by adenosine diphosphate and adrenaline but norma l with collagen. The impairment of blood fibrinolytic activity and pla telet aggregation may have pathogenic and therapeutic implications in malignant atrophic papulosis.