SUPRABASAL ACANTHOLYSIS - AN UNUSUAL FEATURE OF NECROLYTIC MIGRATORY ERYTHEMA

A 67-year-old man with diabetes, weight loss and anaemia initially pre sented with a widespread scaling erythematous rash; a skin biopsy demo nstrated marked suprabasal acantholysis. A subsequent biopsy showed lo calized upper epidermal necrolysis and the diagnosis of glucagonoma sy ndrome was later confirmed. Glucagonoma syndrome should be considered in patients with diabetes, weight loss and anaemia who present with a scaling rash, the histology of which shows suprabasal acantholysis. Th e extent of any upper epidermal necrolysis may be be very limited.