STUDIES OF SELENIUM SUPPLEMENTATION WITH INORGANIC AND COMBINED INORGANIC-ORGANIC SE IN HUMANS

One hundred mug selenium as sodium selenite alone or 50 mug selenium a s selenite and 50 mug selenium as L-selenomethionine along with vitami n E, vitamins B2, B-6 and B-12 were given to two groups of 7 persons/g roup of healthy volunteers for 4 months. The combination of sodium sel enite and L-selenomethionine along with vitamins, Metselen gave signif icant higher concentration of plasma Se than sodium selenite alone. Th e concentration of erythrocyte Se was also significantly higher by sup plementation with Metselen than that of sodium selenite alone. The gro up given Metselen showed significantly higher activity of E-GSH-Px tha n the group given sodium selenite. One month after stopping the supple mentation urinary selenium (24h) of Metselen and sodium selenite retur ned to original values. The combination of sodium selenite, L-selenome thionine along with vitamins was more effective than sodium selenite a lone.