HEMODYNAMIC-EFFECTS OF A NOVEL HYPOTENSIVE PEPTIDE, HUMAN ADRENOMEDULLIN, IN RATS

Authors
ISHIYAMA Y KITAMURA K ICHIKI Y NAKAMURA S KIDA O KANGAWA K ETO T
Citation
Y. Ishiyama et al., HEMODYNAMIC-EFFECTS OF A NOVEL HYPOTENSIVE PEPTIDE, HUMAN ADRENOMEDULLIN, IN RATS, European journal of pharmacology, 241(2-3), 1993, pp. 271-273
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of pharmacology → ACNP
ISSN journal
00142999
Volume
241
Issue
2-3
Year of publication
1993
Pages
271 - 273
Database
ISI
SICI code
0014-2999(1993)241:2-3<271:HOANHP>2.0.ZU;2-M
Abstract
The hemodynamic effects of human adrenomedullin were investigated in a nesthetized Wistar rats. Intravenous administration of adrenomedullin (1.0 nmol/kg) caused a rapid and marked reduction in mean blood pressu re associated with a decrease in total peripheral resistance. This red uction in mean blood pressure was closely correlated with the decrease in total peripheral resistance. These findings indicate that human ad renomedullin is a potent vasodilator and may have some role in the reg ulation of blood pressure.