COMPARISON OF THE EFFECTS OF THE IMMUNOSUPPRESSIVE AGENTS FK-506 AND CYCLOSPORINE-A ON RAT-KIDNEY MITOCHONDRIA

Authors
HENKE W JUNG K
Citation
W. Henke et K. Jung, COMPARISON OF THE EFFECTS OF THE IMMUNOSUPPRESSIVE AGENTS FK-506 AND CYCLOSPORINE-A ON RAT-KIDNEY MITOCHONDRIA, Biochemical pharmacology, 46(5), 1993, pp. 829-832
Citations number
26
Categorie Soggetti
Pharmacology & Pharmacy",Biology
Journal title
Biochemical pharmacology → ACNP
ISSN journal
00062952
Volume
46
Issue
5
Year of publication
1993
Pages
829 - 832
Database
ISI
SICI code
0006-2952(1993)46:5<829:COTEOT>2.0.ZU;2-R
Abstract
Interactions of FK 506 with renal cortical mitochondria have been inve stigated by measuring respiration, ATP net uptake and Ca2+/P(i)-induce d swelling. Both FK 506 and cyclosporin A (CsA) inhibit the succinate- supported state 3 and uncoupled respiration and are without effect on the glutamate/malate-supported state 3 and uncoupled respiration. FK 5 06, like CsA, inhibits net uptake of ATP, but, in contrast to CsA, is without effect on Ca2+/P(i)-induced swelling.