Cs. Rabkin et al., CANCER INCIDENCE TRENDS IN WOMEN AT HIGH-RISK OF HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) INFECTION, International journal of cancer, 55(2), 1993, pp. 208-212
To determine the types and rates of tumors which may be associated wit
h HIV infection in women, we used cancer incidence data from New York
and northern New Jersey. We examined changes in incidence of selected
cancers in women aged 20-49 years and compared groups differing in inc
idence of AIDS. Black women were compared to white women in New York C
ity and in the remainder of New York State; for cervical cancer, rates
were also compared for Blacks and Whites in northern New Jersey. The
incidence of Kaposi's sarcoma in women increased in New York City, beg
inning in 1982 for Blacks and in 1984 for Whites, but remained stable
in the remainder of New York State. The incidence of non-Hodgkin's lym
phoma in New York women doubled in Blacks after 1982 whereas incidence
trends in Whites were unchanged. No consistent variation was seen in
the incidence of Hodgkin's disease. Cervical cancer in New York and no
rthern New Jersey Blacks declined over the same period by approximatel
y 40% for invasive tumors and 50% for in situ lesions. The HIV epidemi
c is associated with substantial excesses of Kaposi's sarcoma and non-
Hodgkin's lymphoma in women. The absence of Kaposi's sarcoma in upstat
e New York women suggests the existence of a geographically restricted
co-factor(s) for Kaposi's sarcoma in addition to HIV. If HIV affected
cervical cancer incidence through 1988, its impact was small compared
to the striking decreases which followed widespread adoption of Papan
icolaou screening. (C) 1993 Wiley-Liss, Inc.