CHRONIC BULLOUS DISEASE OF CHILDHOOD AND ULCERATIVE-COLITIS

A 12-year-old girl with ulcerative colitis (UC) treated by colectomy w ith rectal stump preservation, salazopyrin, and systemic steroids deve loped persistent mouth ulcers, cutaneous targetlike lesions, papulopus tules, and bullae. The clinical, histologic, and immunopathologic feat ures were typical of chronic bullous disease of childhood (CBDC). Alth ough resistant to combined immunosuppressive therapy with low-dose pre dnisolone, cyclosporin, and thalidomide, striking remission of the muc ocutaneous symptoms resulted with surgical resection of the diseased r ectal stump. An etiologic association between CBDC and UC is postulate d.