CIRCLING BEHAVIOR INDUCED BY ACTIVATION OF GABA(A) RECEPTORS IN THE SUBTHALAMIC NUCLEUS

Authors
Citation
Mg. Murer et Jh. Pazo, CIRCLING BEHAVIOR INDUCED BY ACTIVATION OF GABA(A) RECEPTORS IN THE SUBTHALAMIC NUCLEUS, NeuroReport, 4(11), 1993, pp. 1219-1222
Citations number
24
Categorie Soggetti
Neurosciences
Journal title
ISSN journal
09594965
Volume
4
Issue
11
Year of publication
1993
Pages
1219 - 1222
Database
ISI
SICI code
0959-4965(1993)4:11<1219:CBIBAO>2.0.ZU;2-V
Abstract
THE behavioural effect of drugs acting on GABA(A) receptors in the sub thalamic region and the entopeduncular nucleus was studied in freely m oving cats. Microinjections of muscimol into the zona incerta-Forel's fields produced tilt of the head to the injected site, while injection s of bicuculline or picrotoxin produced the same effect but to the opp osite side. Microinjections of muscimol into the subthalamic nucleus e licited circling behaviour to the contralateral side, while bicucullin e and picrotoxin produced ipsilateral turning. However, when high dose s of the antagonists were injected, contralateral circling was observe d. Activation or blockade of GABA(A) receptors into the entopeduncular nucleus was ineffective. These results imply that GABAergic mechanism s in the subthalamic nucleus and the zona incerta-fields of Forel are involved in circling behaviour and vertical head movements, respective ly.