MAKALUVAMINE-G, A CYTOTOXIC PIGMENT FROM AN INDONESIAN SPONGE HISTODERMELLA SP

Authors
CARNEY JR SCHEUER PJ KELLYBORGES M
Citation
Jr. Carney et al., MAKALUVAMINE-G, A CYTOTOXIC PIGMENT FROM AN INDONESIAN SPONGE HISTODERMELLA SP, Tetrahedron, 49(38), 1993, pp. 8483-8486
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
49
Issue
38
Year of publication
1993
Pages
8483 - 8486
Database
ISI
SICI code
0040-4020(1993)49:38<8483:MACPFA>2.0.ZU;2-4
Abstract
A cytotoxic pigment, makaluvamine G (5), biogenetically derivable from tryptamine and tyramine and structurally related to the discorhabdins , was isolated from a sponge of the genus Histodermella collected in I ndonesia. The compound displays significant in vitro cytotoxicity to s everal tumor cell lines and is a moderate inhibitor of topoisomerase-I , DNA, RNA, and protein synthesis.