3 NEW POTENT CYTOTOXIC MACROLIDES CLOSELY-RELATED TO SPHINXOLIDE FROMTHE NEW CALEDONIAN SPONGE NEOSIPHONIA-SUPERSTES

Authors
DAURIA MV PALOMA LG MINALE L ZAMPELLA A VERBIST JF ROUSSAKIS C DEBITUS C
Citation
Mv. Dauria et al., 3 NEW POTENT CYTOTOXIC MACROLIDES CLOSELY-RELATED TO SPHINXOLIDE FROMTHE NEW CALEDONIAN SPONGE NEOSIPHONIA-SUPERSTES, Tetrahedron, 49(38), 1993, pp. 8657-8664
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
49
Issue
38
Year of publication
1993
Pages
8657 - 8664
Database
ISI
SICI code
0040-4020(1993)49:38<8657:3NPCMC>2.0.ZU;2-0
Abstract
Three new macrolides 2-4 have been isolated with sphinxolide 1 from th e marine sponge N. superstes collected off New Caledonia. The structur es of the new compounds were determined by interpretation of NMR spect ral data as well as by comparison of spectral data with those of 1. Th ese compounds were highly cytotoxic against various human carcinoma ce lls.