N. Sales et al., AUTORADIOGRAPHIC LOCALIZATION OF NMDA BINDING-SITES IN BRAIN-STEM CARDIORESPIRATORY AREAS OF ADULT AND NEWBORN CATS, Developmental brain research, 75(1), 1993, pp. 113-118
Quantitative autoradiography was used to determine the distribution of
[H-3]1-[1-(2-thienyl)cyclohexyl] piperidine ([H-3]TCP) binding sites
in the brainstem in order to localize the possible targets activated b
y excitatory amino acids in adult and newborn cats during autonomic rh
ythmic functions. Medium to high densities of binding sites were found
in the nucleus tractus solitarius complex and the laterodorsal part o
f the pontine tegmentum. In the kitten, there was an apparent higher d
ensity in cranial motor nuclei proximal to these structures. It is con
cluded that there is an overlapping between the high density of NMDA r
eceptors and the localization of cardiorespiratory neurons in cat as w
ell as in kitten.