Squamous cell carcinoma of the upper lip is rare and poorly described
in the literature. We analysed retrospectively 123 cases occurring fro
m 1929 to 1987. Greatest incidence was in the seventh decade and the M
/F ratio was 2:1. Treatment was radiotherapy (36) or surgery (87). In
early disease stages radiotherapy and surgery were equally effective,
but in advanced disease surgery provided better results. Involved node
s indicate mandatory laterocervical submandibular lymph node dissectio
n (bilateral for central lesions) but prophylactic dissection is inapp
ropriate. The high frequency of relapse, tendency to plurifocality (as
with all cercicofacial tumors) and risk of lymph node involvement und
erline the importance of regular and careful follow-up.