A MODEL FOR CLEAVAGE OF O-GLYCOSIDIC BONDS IN GLYCOPROTEINS

Authors
IBATULLIN FM GOLUBEV AM FIRSOV LM NEUSTROEV KN
Citation
Fm. Ibatullin et al., A MODEL FOR CLEAVAGE OF O-GLYCOSIDIC BONDS IN GLYCOPROTEINS, Glycoconjugate journal, 10(3), 1993, pp. 214-218
Citations number
26
Categorie Soggetti
Biology
Journal title
Glycoconjugate journal → ACNP
ISSN journal
02820080
Volume
10
Issue
3
Year of publication
1993
Pages
214 - 218
Database
ISI
SICI code
0282-0080(1993)10:3<214:AMFCOO>2.0.ZU;2-X
Abstract
The present work investigated the possibility of cleavage of alpha-lin kages between mannose or galactose and serine/threonine residues by al pha-mannosidase and alpha-galactosidase. The study was carried out ini tially with model synthetic compounds imitating the O-glycosidic bond in glycoproteins, and further with glucoamylase. It was shown that alp ha-mannosidase and alpha-galactosidase can hydrolyse these linkages af ter proteolytic digestion of glucosamylase.