THROMBOSIS AND NEPHOROTIC SYNDROME IN A DOG WITH VISCERAL LEISHMANIASIS

Visceral leishmaniasis with glomerulonephritis and nephrotic syndrome was diagnosed in a six-year-old dog presented with thromboembolic mani festations. A blood coagulation test indicated low levels of antithrom bin III, prolonged partial thromboplastin time, hypofibrinogenaemia, a n increase in fibrin degradation products and decreased plasminogenic activity. These results confirmed the diagnosis of thrombosis induced by glomerulonephritis, accompanied by secondary fibrinolysis. Bone mar row aspiration revealed an abundance of parasites of the genus Leishma nia. Histopathology confirmed the presence of membranous glomeruloneph ritis due to Leishmania species parasites, as well as the presence of thrombosis in the aorta, iliac arteries, vena cava and femoral veni.