INVOLVEMENT OF THIOLS IN THE INDUCTION OF INWARD CURRENT-INDUCED BY SILVER IN FROG SKELETAL-MUSCLE MEMBRANE

Authors
AOKI T NIHONYANAGI K OBA T
Citation
T. Aoki et al., INVOLVEMENT OF THIOLS IN THE INDUCTION OF INWARD CURRENT-INDUCED BY SILVER IN FROG SKELETAL-MUSCLE MEMBRANE, Experientia, 49(9), 1993, pp. 792-794
Citations number
18
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Experientia → ACNP
ISSN journal
00144754
Volume
49
Issue
9
Year of publication
1993
Pages
792 - 794
Database
ISI
SICI code
0014-4754(1993)49:9<792:IOTITI>2.0.ZU;2-G
Abstract
Exposure of voltage-clamped frog skeletal muscle fibres to silver caus ed a maintained inward current which could be carried by Ca2+, Mg2+ or Na+. Inorganic Ca2+ channel blockers and dithiothreitol (SH reducing agent) diminished this current, but a Na+ channel blocker did not. Thu s, silver activates the Ca2+ channel by acting on SH groups in a Ca2channel protein.