EFFECTS OF FLUVOXAMINE ON FOOD-INTAKE DURING REBOUND HYPERPHAGIA IN RATS

We examined the effects of fluvoxamine on food intake during rebound h yperphagia induced by a time-restricted feeding schedule in rats. Rats were allowed access to food for only 2 h daily for 7 days, and then h ad free access to food for 7 consecutive days. The daily food intake o f the rats was dramatically increased, by 42.5% (rebound hyperphagia), for 7 days of the free-feeding period. Intraperitoneal injection of f luvoxamine decreased food intake significantly in a dose-dependent man ner for the first 3 h of feeding during 7 days. When rats were allowed access to one of the standard, carbohydrate-, fat-, or protein-rich d iets in the free-feeding period following the time-restricted feeding schedule, fluvoxamine significantly decreased food intakes of standard , carbohydrate- and fat-rich diets on all days, and the protein-rich d iet after the 2nd day of the free-feeding period. These results indica te that fluvoxamine, irrespective of the diet composition, suppresses rebound hyperphagia induced by a time-restricted feeding schedule, but that its effect is short-lived. (C) 1997 Elsevier Science Inc.