MN-DPDP - ENHANCED MR-IMAGING OF MALIGNANT LIVER-LESIONS - EFFICACY AND SAFETY IN 20 PATIENTS

Citation
Kp. Aicher et al., MN-DPDP - ENHANCED MR-IMAGING OF MALIGNANT LIVER-LESIONS - EFFICACY AND SAFETY IN 20 PATIENTS, Journal of magnetic resonance imaging, 3(5), 1993, pp. 731-737
Citations number
NO
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging
ISSN journal
10531807
Volume
3
Issue
5
Year of publication
1993
Pages
731 - 737
Database
ISI
SICI code
1053-1807(1993)3:5<731:M-EMOM>2.0.ZU;2-3
Abstract
Twenty patients with malignant liver lesions underwent magnetic resona nce (MR) imaging with manganese (II) DPDP [N,N'-dipyridoxylethylenedia mine-N,N'-diacetate 5,5'-bis(phosphate)] to evaluate the safety and ef ficacy of the contrast agent. In two groups of 10 patients each, 5 mum ol/kg Mn-DPDP was administered intravenously (3 mL/min) at a concentra tion of either 50 or 10 mumol/mL. T1- and T2-weighted images were obta ined with a 1.5-T imager. Six patients reported a total of eight insta nces of side effects (flush, feeling of warmth, metallic taste) of whi ch seven occured at the 50 mumol/mL concentration. A significant decre ase in alkaline phosphatase levels 2 hours after injection was recorde d. On T1-weighted images, the 10 mumol/mL formulation yielded signific antly greater increases in contrast-to-noise ratio (79.8%-137.5%) than the 50 mumol/mL formulation (46.2%-86.6%). In a blinded reader study of 10 patients with one to five lesions each, no lesion was missed on Mn-DPDP-enhanced T1-weighted images; however, four false-positive foci were identified. The authors conclude that slow administration of 5 m umol/kg Mn-DPDP at a concentration of 10 mumol/mL is safe and efficien t enough to proceed to further clinical trials.