Kp. Aicher et al., MN-DPDP - ENHANCED MR-IMAGING OF MALIGNANT LIVER-LESIONS - EFFICACY AND SAFETY IN 20 PATIENTS, Journal of magnetic resonance imaging, 3(5), 1993, pp. 731-737
Twenty patients with malignant liver lesions underwent magnetic resona
nce (MR) imaging with manganese (II) DPDP [N,N'-dipyridoxylethylenedia
mine-N,N'-diacetate 5,5'-bis(phosphate)] to evaluate the safety and ef
ficacy of the contrast agent. In two groups of 10 patients each, 5 mum
ol/kg Mn-DPDP was administered intravenously (3 mL/min) at a concentra
tion of either 50 or 10 mumol/mL. T1- and T2-weighted images were obta
ined with a 1.5-T imager. Six patients reported a total of eight insta
nces of side effects (flush, feeling of warmth, metallic taste) of whi
ch seven occured at the 50 mumol/mL concentration. A significant decre
ase in alkaline phosphatase levels 2 hours after injection was recorde
d. On T1-weighted images, the 10 mumol/mL formulation yielded signific
antly greater increases in contrast-to-noise ratio (79.8%-137.5%) than
the 50 mumol/mL formulation (46.2%-86.6%). In a blinded reader study
of 10 patients with one to five lesions each, no lesion was missed on
Mn-DPDP-enhanced T1-weighted images; however, four false-positive foci
were identified. The authors conclude that slow administration of 5 m
umol/kg Mn-DPDP at a concentration of 10 mumol/mL is safe and efficien
t enough to proceed to further clinical trials.