APPLICATION OF A 2-DIMENSIONAL HADAMARD ENCODING MASK FOR THE IMAGINGOF THIN-LAYER CHROMATOGRAPHY PLATES BY LASER-INDUCED FLUORESCENCE OR SURFACE-ENHANCED RAMAN-SCATTERING AND FOR USE WITH A PHOTOACOUSTIC DETECTOR TO GENERATE 3-DIMENSIONAL PHOTOACOUSTIC IMAGES

Spatial imaging of thin-layer chromatography plates using laser-induce d fluorescence and surface-enhanced Raman scattering has been accompli shed with a stationary two-dimensional Hadamard encoding mask. Detecti on of three nanograms of pararosaniline hydrochloride on a thin-layer chromatography plate was made possible by means of the surface-enhance d Raman phenomenon. The imaging capabilities of the stationary two-dim ensional Hadamard encoding mask coupled with the depth profiling abili ty of photoacoustic detection allows for the three-dimensional photoac oustic imaging of a multiple analyte sample.