RENAL-FUNCTION IN PATIENTS PREVIOUSLY TRE ATED FOR WILMS-TUMOR IN INFANCY

The renal function of 60 out 89 patients treated between March 1973 an d May 1992 for Wilms' tumor have been evaluated after 1-20 years (medi an 8.5 years). Renal function has been assessed by means of microalbum inuria, urine examination, serum creatinine, clearance creatinine (ml/ min/1,73 mq), BUN, serum electrolyties, was carried out along with uri c acid and arterial blood pressure. The prevalence of renal damage has been 11,6% (7/60) for microalbuminuria, 5% for renal function deterio ration (3/60 patients with ipercreatininemia and two of them uricemia and hypertension). The time since nephrectomy (> 10 years), has been f ound the only significant parameter related to reduced endogenous crea tinine clearance (ml/min/1,73 mq) and related to blood pressure. The e ndogenous creatinine clearance (mil/min/1,73 mq) has been related to s ex, age at nephrectomy, bilaterality, rime since nephrectomy and treat ment (radiation therapy and chemotherapy) but, no statistically signif icative differences has been found for these parameters. This study re veals the occurence of a possible renal damage in a minority of these patients treated for Wilms' tumor. This late onset complication is not prognostically severe even if warrant a further follow-up.