S. Giacchetti et al., TREATMENT OF STAGE-I TESTIS SEMINOMA BY RADIOTHERAPY - LONG-TERM RESULTS - A 30-YEAR EXPERIENCE, International journal of radiation oncology, biology, physics, 27(1), 1993, pp. 3-9
Citations number
44
Categorie Soggetti
Oncology,"Radiology,Nuclear Medicine & Medical Imaging
Purpose: From 1956 to 1986, we have retrospectively studied 184 patien
ts with a Stage I testis seminoma treated by orchidectomy and radiothe
rapy at the Institut Gustave Roussy. Methods and Materials: The 184 pa
tients received adjuvant radiotherapy to the para-aortic and ipsilater
al iliac nodes. Of the 184 patients, 133 received additional mediastin
al and supraclavicular irradiation, 47 received supraclavicular withou
t mediastinum irradiation, 98 patients received additional radiotherap
y given to inguino-scrotal area. The mean dose of irradiation is 21 Gy
which is the lowest dose published. The actuarial survival rate is, r
espectively, 96%, 93%, 83% and 77% at 5, 10, 15, and 20 years. Results
: Four patients relapsed, and four died of progressive disease. Four p
atients presented cardiovascular disease, all of them had mediastinal
irradiation, two were heavy smokers. Seventeen second malignancies wer
e observed, six tumors in the controlateral testis. The actuarial risk
of developing a second malignancy is 10% at 10 years, 21% at 20 years
. The cure rate and relapse rate in our patients is the same as that o
btained by higher dosage of irradiation. Conclusion: We conclude that
low dose of prophylactic irradiation in lombo aortic and ipsilateral i
liac lymph nodes is active and safe in the treatment of Stage I testis
seminoma.