Fifty-one patients in whom a clinical diagnosis of acute appendicitis
had been made underwent peritoneal aspiration cytology (PAC). Thirty-s
ix had a positive result, 11 had a negative result and aspiration fail
ed in four cases. All patients had an appendicectomy and the histologi
cal findings were correlated with the PAC results. Thirty-rive of the
36 patients with a positive PAC had histologically proven appendicitis
. Seven or the 11 patients with a negative result had normal appendice
s. The sensitivity of PAC for acute appendicitis was 85% and the speci
ficity was 70%. The positive predictive value was found to be 97% and
the negative predictive value 60%. Peritoneal aspiration cytology is a
useful aid in the diagnosis of acute appendicitis however, a negative
result does not exclude this diagnosis.