A PROSPECTIVE RANDOMIZED COMPARISON OF ZYGOTE INTRAFALLOPIAN TRANSFERAND IN-VITRO FERTILIZATION-EMBRYO TRANSFER FOR NONTUBAL FACTOR INFERTILITY

Objective: To evaluate the efficacy of zygote intrafallopian transfer (ZIFT) versus standard IVF-ET for the treatment of nontubal factor inf ertility. Design: A prospective randomized trial. Participants: Fifty- nine couples undergoing oocyte retrieval for nontubal infertility in a university hospital-based IVF-ET program. Interventions: A maximum of four cleaving embryos were transferred into the fallopian tube or ute rine cavity 48 or 55 hours after oocyte retrieval, respectively. Main Outcome Measures: Rates of implantation, pregnancy, and spontaneous ab ortion (SAB) were compared. Results: Clinical pregnancies occurred aft er 26.5% versus 12% of retrievals and 29% versus 14.3% of transfers in IVF-ET versus ZIFT cycles, respectively. Pregnancy, implantation, and SAB rates did not differ between the groups. Conclusions: This prospe ctive randomized trial failed to demonstrate any therapeutic improveme nt associated with the increased complexity of ZIFT as compared with s tandard IVF ET.