A PATIENT WITH TN SYNDROME-ASSOCIATED WITH MYELODYSPLASTIC SYNDROME SHOWED ABNORMAL GLYCOPHORIN-B

A Japanese male patient with myelodysplastic syndrome (MDS) was shown to have associated Tn syndrome; the first report of Tn syndrome with M DS. The Tn expression was demonstrated on erythrocytes, granulocytes, monocytes, platelets, and lymphocytes by flow cytometric analysis usin g a lectin and an antibody. Electrophoresis of erythrocyte membrane pr oteins revealed slower mobility of glycophorin B from the patient than that from normal individuals, suggesting a glycophorin B molecular ab normality.