EYE TRACKING DYSFUNCTION AND SCHIZOPHRENIA - A CRITICAL PERSPECTIVE

Eye tracking dysfunction (ETD) has been found in large numbers of schi zophrenia patients and their first-degree relatives. Because of the ma ny replications of the central findings, ETD has been proposed as a us eful way of expanding the schizophrenia phenotype in genetic studies. We critically review the literature on ETD with respect to issues of m easurement and the search for quantitative indices of ETD; syndrome an d familial specificity of ETD for schizophrenia; statistical, interpre tive, and methodological considerations in the use of mixture analysis ; the association of ETD with clinically and psychometrically defined schizotypy; and the questions of trait stability and medication effect s.