DETERMINANTS OF GENITAL HUMAN PAPILLOMAVIRUS INFECTION IN LOW-RISK WOMEN IN PORTLAND, OREGON

Objectives: To confirm the risk factors for genital human papillomavir us (HPV) infection. Goal of this study: To investigate risk factors fo r HPV detection independent of the correlated risk factors for cervica l neoplasia in a low-risk population. Study Design: HPV DNA was assess ed among 483 cytologically normal women with no known history of cervi cal neoplasia. A cervicovaginal lavage was collected for HPV detection and typing using a PCR-based DNA amplification system. Information on risk factors of subjects was obtained through a questionnaire. Result s: HPV DNA was found in 17.7% of study women. On univariate analysis, factors associated with increasing HPV prevalence included younger age , fewer years of education, lower income, higher lifetime number of se x partners, lower age at first intercourse, nulliparity, oral contrace ptive use, and current smoking. After statistical adjustment, we found younger age and higher number of sex partners were strongly and indep endently associated with higher HPV prevalence. We also observed incre ased HPV prevalence among women with lower levels of education and low er incomes. Conclusion: These findings and corroborative data from the companion reports in this issue of the journal support the sexual rou te of transmission of the virus.