APPLICATIONS OF DUAL-BEAM THERMOSPRAY LIQUID-CHROMATOGRAPHY MASS-SPECTROMETRY

A dual-beam thermospray system has been constructed, by which the requ irements of the electrolyte ion evaporation process have been decouple d from those of the separation and volatilization of the analytes. The dual-beam system has a high flexibility with regard to mobile phase p olarity, flow-rate and eluent vaporizer temperature. Results are prese nted from applications of dual-beam thermospray in the coupling of org anic gel permeation chromatography with mass spectrometry, and in grad ient elution liquid chromatography. In a comparison of the dual-beam w ith the single-beam thermospray technique for two thermolabile compoun ds, the mass spectra obtained with the dual-beam system show much less degradation.