DETERMINATION OF PENICILLAMINE OR TIOPRONIN IN PHARMACEUTICAL PREPARATIONS BY FLOW-INJECTION ANALYSIS

Authors
GARCIA MS SANCHEZPEDRENO C ALBERO MI RODENAS V
Citation
Ms. Garcia et al., DETERMINATION OF PENICILLAMINE OR TIOPRONIN IN PHARMACEUTICAL PREPARATIONS BY FLOW-INJECTION ANALYSIS, Journal of pharmaceutical and biomedical analysis, 11(8), 1993, pp. 633-638
Citations number
25
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Journal of pharmaceutical and biomedical analysis → ACNP
ISSN journal
07317085
Volume
11
Issue
8
Year of publication
1993
Pages
633 - 638
Database
ISI
SICI code
0731-7085(1993)11:8<633:DOPOTI>2.0.ZU;2-H
Abstract
Two flow injection analysis (FIA) methods, using spectrophotometric de tection, are proposed for the determination of penicillamine or tiopro nin [N-(2-mercaptopropionylglycine)]. The procedures are based on the formation of yellow complexes between these thiol-containing drugs and Pd(II), in a 1 M or 0.25 M HCl medium, respectively. With peak height as a quantitative parameter, penicillamine is determined over the ran ge 1.0 x 10(-5)-7.0 x 10(-4) M; for tiopronin the range is 1.0 x 10(-5 )-6.0 x 10(-4) M. The methods have been applied to the routine determi nation of the drugs in pharmaceutical preparations.