DEUTERIUM NMR-SPECTROSCOPY OF BIOFLUIDS FOR THE IDENTIFICATION OF DRUG METABOLITES - APPLICATION TO N,N-DIMETHYLFORMAMIDE

Authors
FARRANT RD SALMAN SR LINDON JC CUPID BC NICHOLSON JK
Citation
Rd. Farrant et al., DEUTERIUM NMR-SPECTROSCOPY OF BIOFLUIDS FOR THE IDENTIFICATION OF DRUG METABOLITES - APPLICATION TO N,N-DIMETHYLFORMAMIDE, Journal of pharmaceutical and biomedical analysis, 11(8), 1993, pp. 687-692
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Journal of pharmaceutical and biomedical analysis → ACNP
ISSN journal
07317085
Volume
11
Issue
8
Year of publication
1993
Pages
687 - 692
Database
ISI
SICI code
0731-7085(1993)11:8<687:DNOBFT>2.0.ZU;2-M
Abstract
The metabolism of N,N-dimethylformamide in the Sprague-Dawley rat has been reinvestigated using NMR spectroscopy of urine. In particular, th rough the use of N,N-dimethylformamide-d7 (DMF-d7) and H-2-NMR spectro scopy, the principal metabolites of this compound have been confirmed in a direct manner. The use of inverse-detected two-dimensional H-2-C- 13 correlation with C-13 decoupling aided metabolite identification th rough the provision of C-13 chemical shifts.