THE SUITABILITY OF CARBOPLATIN SOLUTIONS FOR 14-DAY CONTINUOUS-INFUSION BY AMBULATORY PUMP - AN HPLC-DYNAMIC FAB STUDY

Authors
HADFIELD JA MCGOWN AT DAWSON MJ THATCHER N FOX BW
Citation
Ja. Hadfield et al., THE SUITABILITY OF CARBOPLATIN SOLUTIONS FOR 14-DAY CONTINUOUS-INFUSION BY AMBULATORY PUMP - AN HPLC-DYNAMIC FAB STUDY, Journal of pharmaceutical and biomedical analysis, 11(8), 1993, pp. 723-727
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Journal of pharmaceutical and biomedical analysis → ACNP
ISSN journal
07317085
Volume
11
Issue
8
Year of publication
1993
Pages
723 - 727
Database
ISI
SICI code
0731-7085(1993)11:8<723:TSOCSF>2.0.ZU;2-1
Abstract
The stability of aqueous carboplatin solutions over 14 days has been s tudied at 37 and 60-degrees-C. High-performance liquid chromatography and dynamic FAB mass spectrometry studies have shown that carboplatin solutions were stable at 37-degrees-C but degraded at 60-degrees-C. Fl uid loss through evaporation was significant at the higher temperature .