BOVINE HYPERKERATOSIS - HISTORICAL REVIEW AND REPORT OF AN OUTBREAK

Occasional cases of bovine hyperkeratosis occur despite removal of sou rces of highly chlorinate naphthalenes from agriculture-related uses. Disease is clinically characterized by lacrimation, salivation, weight loss, and by a diffuse. nonpruritic. proliferative dermatopathy. Prec ipitous reduction of serum vitamin A levels is an early, prolonged, an d highly significant feature of the intoxication. Diagnostically signi ficant lesions occur in the male and female genital tracts, the liver and biliary system, the pancreas, kidneys, and other organs. Squamous metaplasia and impaction of meibomian glands are salient lesions of hi ghly chlorinated naphthalene toxicosis.