BOTULINUM ANTIBODIES IN DYSTONIC PATIENTS TREATED WITH TYPE-A BOTULINUM TOXIN - FREQUENCY AND SIGNIFICANCE

Authors
ZUBER M SEBALD M BATHIEN N DERECONDO J RONDOT P
Citation
M. Zuber et al., BOTULINUM ANTIBODIES IN DYSTONIC PATIENTS TREATED WITH TYPE-A BOTULINUM TOXIN - FREQUENCY AND SIGNIFICANCE, Neurology, 43(9), 1993, pp. 1715-1718
Citations number
14
Categorie Soggetti
Clinical Neurology
Journal title
Neurology → ACNP
ISSN journal
00283878
Volume
43
Issue
9
Year of publication
1993
Pages
1715 - 1718
Database
ISI
SICI code
0028-3878(1993)43:9<1715:BAIDPT>2.0.ZU;2-E
Abstract
We measured serum antibodies to botulinum toxin (ABT) in 96 patients w ith focal dystonia who had been treated with type A botulinum toxin. T he frequency of detectable ABT was 3% (three patients). Patients with ABT had received more than 50 ng of botulinum toxin, and the shortest time between two injections was significantly less than in patients wi thout ABT. The clinical evolution of the three patients was heterogene ous: one had decreased effectiveness with repeated injections, another had persistent improvement, and the third never responded to toxin in jections.