POSITRON EMISSION TOMOGRAPHY AND HISTOPATHOLOGY IN CREUTZFELDT-JAKOB-DISEASE

Authors
GOLDMAN S LIARD A FLAMENTDURAND J LUXEN A BIDAUT LM STANUS E HILDEBRAND J PRZEDBORSKI S
Citation
S. Goldman et al., POSITRON EMISSION TOMOGRAPHY AND HISTOPATHOLOGY IN CREUTZFELDT-JAKOB-DISEASE, Neurology, 43(9), 1993, pp. 1828-1830
Citations number
10
Categorie Soggetti
Clinical Neurology
Journal title
Neurology → ACNP
ISSN journal
00283878
Volume
43
Issue
9
Year of publication
1993
Pages
1828 - 1830
Database
ISI
SICI code
0028-3878(1993)43:9<1828:PETAHI>2.0.ZU;2-K
Abstract
We studied a 62-year-old man with Creutzfeldt-Jakob disease (CJD), usi ng positron emission tomography (PET) and (F-18)-2-fluoro-2-deoxy-D-gl ucose (FDG). Glucose metabolism was heterogeneously decreased througho ut the brain. At autopsy, regional distributions of spongiosis, astrog liosis, and neuronal loss correlated with premortem regional metabolic deficits. These results suggest that PET with FDG may provide metabol ic regional markers for CJD neuropathology.