PLASMA-CONCENTRATIONS OF INORGANIC SULFATE IN ALZHEIMERS-DISEASE

Recent reports have suggested that plasma concentrations of inorganic sulfate may be lower in patients with Alzheimer's disease (AD). We mea sured sulfate concentrations in 10 patients with AD and found an avera ge concentration of 0.28 mM, which was not significantly different fro m the mean concentration in age-matched controls (0.32 mM) or young he althy controls (0.27 mM). These results indicate that plasma sulfate c oncentrations are not altered in AD and that previous reports suggesti ng altered metabolism of sulfur-containing xenobiotics in neurodegener ative diseases should be reevaluated.