W. Zieleniewski, EFFECT OF NILVADIPINE ON ADRENOCORTICAL CELL-PROLIFERATION AND STEROIDOGENESIS IN EARLY-STAGE OF ADRENAL REGENERATION, Experimental and toxicologic pathology, 45(4), 1993, pp. 245-247
The influence of nilvadipine, a novel calcium channel antagonist on ad
renal regeneration was investigated in male Wistar rats. The estimatio
n of the mitotic index after administration of colchicine was suppleme
nted by an immunoperoxidase technique with monoclonal antibodies to br
omodeoxyuridine. Plasma corticosterone was determined by a radioimmuno
logical assay. Nilvadipine was given subcutaneously in two doses (0.2
and 1 mg/kg) to animals subjected to adrenal enucleation combined with
contralateral adrenalectomy. It was found that nilvadipine inhibited
the proliferation ratio of adrenocortical cells on the 4th day after s
urgery in a dose-dependent manner. The inhibitory effect of nilvadipin
e became less significant by 8 days after operation. However, no chang
es in corticosterone secretion were observed.