PROTEINS IMMUNOLOGICALLY RELATED TO ERYTHROCYTE ANION TRANSPORTER BAND-3 ARE ALTERED IN BRAIN-AREAS AFFECTED BY ALZHEIMERS-DISEASE

Authors
BOSMAN GJCGM VANWORKUM FPA RENKAWEK K VANKALMTHOUT PJC BARTHOLOMEUS IGP DEGRIP WJ
Citation
Gjcgm. Bosman et al., PROTEINS IMMUNOLOGICALLY RELATED TO ERYTHROCYTE ANION TRANSPORTER BAND-3 ARE ALTERED IN BRAIN-AREAS AFFECTED BY ALZHEIMERS-DISEASE, Acta Neuropathologica, 86(4), 1993, pp. 353-359
Citations number
35
Categorie Soggetti
Neurosciences
Journal title
Acta Neuropathologica → ACNP
ISSN journal
00016322
Volume
86
Issue
4
Year of publication
1993
Pages
353 - 359
Database
ISI
SICI code
0001-6322(1993)86:4<353:PIRTEA>2.0.ZU;2-S
Abstract
Proteins immunologically related to the human erythrocyte anion transp orter band 3 are present in neurons of the human neocortex and hippoca mpus. Immunocytochemical studies show increased band 3 immunoreactivit y in neurons in the brains of patients with Alzheimer's disease. Immun oblot studies show the presence of band 3-like molecules in brain memb rane fractions, and suggest changes in expression and/or processing of band 3-like molecules in Alzheimer's disease-affected regions.We post ulate that alterations in membrane-bound, band 3-like molecules may re flect termination of neuronal lifespan in Alzheimer's disease.