HIGH-RESOLUTION IMAGING OF NATIVE BIOLOGICAL SAMPLE SURFACES USING SCANNING PROBE MICROSCOPY

The possibility of acquiring high resolution topographs using scanning probe microscopes under physiological conditions allows the observati on of biomolecules at work. Progress has recently been made in imaging protein-DNA complexes, individual oligomers and protein arrays. Scann ing probe microscopes are now tools that complement X-ray crystallogra phy and electron microscopy.