ACUTE MATERNAL RENAL-INSUFFICIENCY IN PREMATURE LABOR TREATED WITH INDOMETHACIN

Three cases of acute renal insufficiency in pregnant women who were tr eated with indomethacin for premature labor are reported. At the time of presentation, all three women had normal renal function but within 30 hours of indomethacin therapy they were noted to have significant d ecreases in urine output and rising serum creatinines. The average tim e to recovery of renal function was 5 days. A consistent feature in al l three women was the development of dyspnea associated with hypoxemia .