SUCCESSFUL TREATMENT WITH HYDROCHLOROTHIAZIDE AND AMILORIDE IN AN INFANT WITH CONGENITAL NEPHROGENIC DIABETES-INSIPIDUS

We report a 9-month-old male Latino infant with congenital nephrogenic diabetes insipidus (NDI) who presented with hypernatremic dehydration aggravated by severe gastroenteritis. Initially, the infant was manag ed with intravenous fluids followed by standard 20 cal/ounce formula a nd pharmacological therapy, resulting in normalization of his serum so dium level. While hydrochlorothiazide therapy alone or in combination with prostaglandin inhibitors or amiloride has been successful in chil dren and adolescents, this is the first report of the successful use o f hydrochlorothiazide and amiloride in an infant with congenital NDI.