P-31 MAGNETIC-RESONANCE SPECTROSCOPY INVESTIGATION OF SKELETAL-MUSCLEMETABOLISM IN UREMIC PATIENTS

Using the method of in vivo magnetic resonance spectroscopy we examine d 17 patients with moderately advanced chronic renal insufficiency, 21 patients with chronic renal failure.treated by haemodialysis, and 15 dialyzed patients with symptomatic renal osteopathy. The ratios of int racellular phosphocreatine and inorganic phosphate concentrations of t hese subjects measured at rest were compared with those found in healt hy controls. While we noted significantly lower (p < 0.01) ratio value s in all patients, subjects with osteopathy showed a lower value than dialyzed patients free of bone disease. Haemodialysis improved the res ult of examination in 7 patients. The results can be summarized as fol lows: (1) patients with altered renal function have significantly impa ired energy metabolism of skeletal muscle, and (2) the disorder is mor e severe in patients with renal osteopathy than in those free of it.