To clarify the rise in plasma creatinine concentration previously obse
rved during prednisone treatment, we studied changes in renal function
in Graves' ophthalmopathy patients before and after 2 weeks of either
prednisone 60 mg/day or retrobulbar radiotherapy (controls). Compared
to retrobulbar radiotherapy, prednisone treatment was associated with
an increase in: (a) plasma creatinine concentration (from 68 +/- 4 to
76 +/- 4 mumol/1), (b) glomerular filtration rate (GFR, from 93 +/- 4
to 102 +/- 5 ml/min/1.73 m2), and (c) urinary creatinine excretion ra
te (from 510 +/- 40 to 570 +/- 40 mumol/h). We conclude that GFR rises
during 2 weeks of high-dose prednisone administration, a rise that is
not reflected by a decrease in plasma creatinine concentration. On th
e contrary, both plasma creatinine concentration and urinary creatinin
e excretion increase, probably as a result of the catabolic effect of
prednisone. As established by the present study, prednisone 60 mg/day
is associated with protein wasting, also after 14 days of treatment.