Cystectomy remains one of the standard treatments for women with local
ly advanced (stage C) urethral cancer, or stage A or B lesions that ha
ve failed radiation therapy. Often, the urethral neoplasm does not inv
ade the bladder. We treated 5 women with stage C urethral cancer by wi
de local excision with or without concomitant radiation therapy, while
preserving the bladder. Local control was achieved in all patients wi
th followup ranging from 4 to 75 months (median 42). We believe that b
ladder sparing treatment strategies should be considered for selected
stage C tumors when the bladder is not invaded by the neoplasm.