INTERLEUKIN-1-BETA INDUCES CYTOSOLIC PLA2 IN PARALLEL WITH PROSTAGLANDIN E(2) IN RHEUMATOID SYNOVIAL FIBROBLASTS

Authors
HULKOWER KI COFFEY JW LEVIN W ANDERSON CM CHEN T HOPE WC BOLIN DR MORGAN DW
Citation
Ki. Hulkower et al., INTERLEUKIN-1-BETA INDUCES CYTOSOLIC PLA2 IN PARALLEL WITH PROSTAGLANDIN E(2) IN RHEUMATOID SYNOVIAL FIBROBLASTS, Agents and actions, 39, 1993, pp. 30000005-30000007
Citations number
5
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Agents and actions → ACNP
ISSN journal
00654299
Volume
39
Year of publication
1993
Pages
30000005 - 30000007
Database
ISI
SICI code
0065-4299(1993)39:<30000005:IICPIP>2.0.ZU;2-W
Abstract
We investigated the temporal relationship between the increase in enzy matic activity and protein of a high molecular weight (100 kDa), cytos olic PLA2 (cPLA2) in interleukin-1beta (IL-1beta)-treated rheumatoid s ynovial fibroblasts (RSF). Both of these responses increased according to a similar time-course which correlates with PGE2 production by the se cells. In contrast, 14 kDa, secreted PLA2 (sPLA2), which was also p roduced by RSF, was not affected by IL-1beta treatment. These findings support that an augmentation of cPLA2 activity, caused by an inductio n of cPLA2 protein, rather than sPLA2, is temporally associated with i ncreased PGE2 production in IL-1beta-treated RSF.